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Effects of Alpha- And Beta-Adrenoceptor Agonists and a Phosphodiesterase Inhibitor (ICI 63 197) on Cyclic AMP and GMP Levels in Bovine Splenic Nerve

Effects of Alpha- And Beta-Adrenoceptor Agonists and a Phosphodiesterase Inhibitor (ICI 63 197) on Cyclic AMP and GMP Levels in Bovine Splenic Nerve

Z Merican, M W Nott

Clin Exp Pharmacol Physiol. Jan-Feb 1983;10(1):35-44.

PMID: 6132692

Abstract:

1. Cyclic AMP and cyclic GMP levels were determined in bovine splenic nerve segments in the absence and presence of (+/-)-isoprenaline, (-)-phenylephrine, clonidine and ICI 63 197 (a phosphodiesterase inhibitor). The chosen concentrations of adrenoceptor agonists were those which are known to affect stimulation-induced overflow of noradrenaline from nerve terminals. 2. The mean levels of cyclic AMP ranged from 229 to 555 pmol/g of microwave irradiated tissue. Mean cyclic GMP levels ranged from 27.9 to 42.2 pmol/g. 3. Isoprenaline enhanced cyclic AMP levels but did not affect cyclic GMP levels. The effect was blocked with (+/-)-propranolol. ICI 63 197 increased cyclic AMP levels but did not change cyclic GMP. Phenylephrine and clonidine caused no consistent changes in cyclic AMP or cyclic GMP levels or in the concentration ratio between these two nucleotides. 4. The results support the involvement of cyclic AMP in the enhancing effect of beta-adrenoceptor agonists and phosphodiesterase inhibitors on stimulation-induced release of noradrenaline from sympathetic nerves.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP27277005	ICI 63,197		27277-00-5	Price

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