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Effects of Alpha-Tocopherol-Nicotinate Administration on the Microdynamics of Phospholipids of Erythrocyte Membranes in Human Subjects

T Koyama, T Araiso

J Nutr Sci Vitaminol (Tokyo). 1988 Oct;34(5):449-57.

PMID: 3230416

Abstract:

The effects of alpha-tocopherol-nicotinate on the microdynamic parameters, membrane viscosity, and wobbling angle of phospholipid molecules of healthy human erythrocyte membranes were studied with a nanosecond time-resolved fluorometer. The incorporation of alpha-tocopherol was achieved by oral administration of alpha-tocopherol-nicotinate for one month with dosage of 400 mg/day. The increase in alpha-tocopherol concentration in erythrocytes was confirmed in two subjects. The membrane viscosity in seven healthy subjects decreased significantly from 1.015 +/- 0.137 to 0.888 +/- 0.133 mPa.s. But no changes in the wobbling angle of phospholipid molecules were observed.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP51898341 (±)-α-Tocopherol nicotinate (±)-α-Tocopherol nicotinate 51898-34-1 Price
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