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Effects of Azatadine Maleate on Subjective Appraisal and Psychomotor Functions Relevant to Driving Performance

Effects of Azatadine Maleate on Subjective Appraisal and Psychomotor Functions Relevant to Driving Performance

B Biehl

Curr Med Res Opin. 1979;6(1):62-9.

PMID: 37045

Abstract:

Studies were carried out in normal healthy male subjects to assess the effects on psychomotor functions and subjective ratings of performance after acute administration of azatadine maleate, a potent antihistamine with additional antiserotonin activity. In the first trial, 2 mg azatadine was compared with another new antihistamine Sch 12169 (2 mg) and placebo. In a second trial, higher doses of azatadine (4 mg and 8 mg) were compared with dexchlorpheniramine (4 mg) and placebo. Both trials were of a double-blind, randomized Latin square design and subjects were assessed using a battery of tests, after administration of each trial drug. The time and sequence of tests were standarized, with a 1-week interval between test sessions. The results showed that azatadine did not produce significant impairment of psychomotor function at either the standard 2 mg or the maximum recommended 4 mg per day dosage level. Permormance was only significantly impaired, compared with that after placebo, at the 8 mg dose level and was of a similar order to that observed after dexchlorpheniramine at the usual 4 mg dosage. It is suggested, therefore, that at the normal recommended dosage of 2 mg per day, azatadine is not likely to impair driving ability.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3978867	Azatadine maleate		3978-86-7	Price

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