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Effects of Bromide Upon Reaction of Nucleosides With Hydrogen Peroxide Induced by Ultraviolet Light

Effects of Bromide Upon Reaction of Nucleosides With Hydrogen Peroxide Induced by Ultraviolet Light

Toshinori Suzuki, Naofumi Moriwaki, Kazuko Kurokawa, Michiyo Inukai

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3217-9.

PMID: 19428243

Abstract:

When ultraviolet light was irradiated on a neutral solution of deoxynucleosides and hydrogen peroxide, concentrations of all the deoxynucleosides decreased greatly. Addition of bromide in the system suppressed the reactions of 2'-deoxycytidine, 2'-deoxythymidine, and 2'-deoxyadenosine, but not that of 2'-deoxyguanosine. Addition of hydroxyl radical scavengers suppressed the reaction. The effect of deuterium oxide, an enhancer of singlet oxygen, was small. It is reported that hydroxyl radical, generating from hydrogen peroxide by ultraviolet irradiation, can react with bromide forming bromine radical, and that bromine radical reacts with bromide forming dibromide radical anion. Our result of dose dependency of bromide suggests that dibromide radical anion is the reaction species to react only with 2'-deoxyguanosine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13536599-A	Deuterium bromide solution		13536-59-9	Price

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