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Effects of Carbon Dots Surface Functionalities on Cellular Behaviors - Mechanistic Exploration for Opportunities in Manipulating Uptake and Translocation

Effects of Carbon Dots Surface Functionalities on Cellular Behaviors - Mechanistic Exploration for Opportunities in Manipulating Uptake and Translocation

Gui-Hua Yan, Zheng-Mei Song, Yuan-Yuan Liu, Qianqian Su, Weixiong Liang, Aoneng Cao, Ya-Ping Sun, Haifang Wang

Colloids Surf B Biointerfaces. 2019 Sep 1;181:48-57.

PMID: 31121381

Abstract:

Carbon dots (CDots) for their excellent optical and other properties have been widely pursued for potential biomedical applications, in which a more comprehensive understanding on the cellular behaviors and mechanisms of CDots is required. For such a purpose, two kinds of CDots with surface passivation by 3-ethoxypropylamine (EPA-CDots) and oligomeric polyethylenimine (PEI-CDots) were selected for evaluations on their uptakes by human cervical carcinoma HeLa cells at three cell cycle phases (G0/G1, S and G2/M), and on their different internalization pathways and translocations in cells. The results show that HeLa cells could internalize both CDots by different pathways, with an overall slightly higher internalization efficiency for PEI-CDots. The presence of serum in culture media could have major effects, significantly enhancing the cellular uptake of EPA-CDots, yet markedly inhibiting that of PEI-CDots. The HeLa cells at different cell cycle phases have different behaviors in taking up the CDots, which are also affected by the different dot surface moieties and serum in culture media. Mechanistic implications of the results and the opportunities associated with an improved understanding on the cellular behaviors of CDots for potentially the manipulation and control of their cellular uptakes and translocations are discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6291856	3-Ethoxypropylamine		6291-85-6	Price

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