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Effects of Chitosan Derivative N-[(2-Hydroxy-3-Trimethylammonium)Propyl]Chloride on Anticoagulant Activity of Guinea Pig Plasma

N N Drozd, B Ts Shagdarova, A V Il'ina, V P Varlamov

Bull Exp Biol Med. 2017 Jul;163(3):340-343.

PMID: 28744652

Abstract:

Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 70 aIIa U/kg non-fractionated heparin shortened plasma clotting time (shown by partial activated thromboplastin time, thrombin time, and prothrombin time). Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 1 mg/kg (100 aXa U/kg) low-molecular-weight heparin (clexane) led to shortening of plasma clotting time in the ReaClot Heparin test and to prolongation of plasma amidolytic activity in the factor Xa chromogenic substrate test.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR4246512 Factor Xa chromogenic substrate Factor Xa chromogenic substrate Price
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