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Effects of Deuterium Oxide on Cell Growth and Vesicle Speed in RBL-2H3 Cells

Roshni S Kalkur, Andrew C Ballast, Ashley R Triplett, Kathrin Spendier

PeerJ. 2014 Sep 2;2:e553.

PMID: 25237603

Abstract:

For the first time we show the effects of deuterium oxide on cell growth and vesicle transport in rat basophilic leukemia (RBL-2H3) cells. RBL-2H3 cells cultured with 15 moles/L deuterium showed decreased cell growth which was attributed to cells not doubling their DNA content. Experimental observations also showed an increase in vesicle speed for cells cultured in deuterium oxide. This increase in vesicle speed was not observed in deuterium oxide cultures treated with a microtubule-destabilizing drug, suggesting that deuterium oxide affects microtubule-dependent vesicle transport.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP7789200-A Deuterium oxide Deuterium oxide 7789-20-0 Price
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