Home
Resources
Publications
Effects of Ethanol Extract of Ficus Bengalensis (Bark) on Inflammatory Bowel Disease

Effects of Ethanol Extract of Ficus Bengalensis (Bark) on Inflammatory Bowel Disease

Manish Amerutlal Patel, Paras Kantibhai Patel, Manish B Patel

Indian J Pharmacol. 2010 Aug;42(4):214-8.

PMID: 20927245

Abstract:

Objective:
The present study was designed to evaluate the effects of ethanol extract of Ficus bengalensis Linn. bark (AEFB) on inflammatory bowel disease (IBD).
Materials and methods:
Effects of AEFB were studied on 2,4,6-trinitrobenzenesulfonic acid (TNBS, 0.25 ml 120 mg/ml in 50% ethanol intrarectally, on first day only) induced IBD in rats. The effects of co-administration of prednisolone (2 mg/kg) and AEFB (250, 500 mg/kg) for 21 days were evaluated. Animals sacrificed at end of the experiment and various histopathological parameters like colon mucosal damage index (CMDI) and disease activity index (DAI) were assessed. In the colon homogenate malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), and nitric oxide (NO) levels and in mesentery % mast cell protection was also measured.
Results:
Rats treated with only TNBS showed more score of CMDI and DAI, higher MDA, NO, MPO, and lower SOD activity as compared to the control group. Treatment with AEFB significantly declined both indices scores and decreased the MPO, MDA, NO, and increased the SOD activity. AEFB also increased the % mast cell protection compared to alone TNBS-treated animals.
Conclusion:
In our study, we found that AEFB has a significant protective effect in the IBD in rats that is comparable to that of prednisolone and may be because of the presence of flavonoids, terpenoids, and phenolic compounds.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS37225	Prednisolone-2,4,6,6,21,21-d6			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: