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Effects of Fenoldopam Mesylate on Central Hemodynamics and Renal Flow in Patients Undergoing Cardiac Surgery: Color Doppler Echocardiographic Evaluation

Effects of Fenoldopam Mesylate on Central Hemodynamics and Renal Flow in Patients Undergoing Cardiac Surgery: Color Doppler Echocardiographic Evaluation

Massimo Meco, Silvia Cirri

J Cardiothorac Vasc Anesth. 2010 Feb;24(1):58-62.

PMID: 19553140

Abstract:

Objective:
The purpose of this study was to evaluate the effect of 0.1 microg/kg/min of fenoldopam mesylate on renal flow and central hemodynamics measured by echocardiography in hemodynamically stable patients with preserved renal function undergoing cardiac surgery.
Design:
Experimental observational study.
Setting:
Single-institutional community hospital study.
Participants:
Thirty patients undergoing cardiac surgery.
Intervention:
Fenoldopam mesylate infusion (0.1 microg/kg/min) in patients undergoing cardiopulmonary bypass.
Measurements and main results:
Doppler measurements of renal blood flow and echocardiographic hemodynamic determinations after Doppler echocardiography measured flux velocities of the main, segmental, and interlobar and interlobular right renal arteries. The authors calculated the resistive index of all the renal segments studied. Moreover, the authors measured the flux of the main renal artery and its diameter as well as the main hemodynamic variables. All the measurements were performed in the intensive care unit setting at baseline and 20 minutes after the infusion of 0.1 microg/kg/min of fenoldopam mesylate. Fenoldopam mesylate infusion significantly increased blood flow in all renal compartments, thus improving the resistive index. The study showed that fenoldopam mesylate infusion does not induce any significant change of the heart rate or arterial pressure, cardiac output, preload, or wall stress.
Conclusions:
In hemodynamically stable cardiac surgery patients with preserved renal function, an infusion of 0.1 microg/kg/min of fenoldopam mesylate has no influence on systemic hemodynamics while increasing renal blood flow.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP67227570-A	Fenoldopam mesylate		67227-57-0	Price

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