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Effects of FPL-55712 or Indomethacin on Leukotriene-Induced Coronary Constriction in the Intact Pig Heart

L M Boyd, D Ezra, G Feuerstein, R E Goldstein

Eur J Pharmacol. 1983 May 6;89(3-4):307-11.

PMID: 6873166

Abstract:

Intracoronary leukotriene D4, 0.1-3.0 micrograms (0.2-6.0 nmol), produced dose-dependent decreases in coronary flow of anesthetized pigs. Pretreatment with intracoronary FPL-55712 (0.1, 0.3 and 1.0 mg) reduced coronary constriction due to 1.0 micrograms leukotriene D4 by up to 77%. FPL-55712 did not produce sustained alterations in coronary flow, left ventricular end-diastolic pressure, systemic arterial pressure, or heart rate. Indomethacin pretreatment (6 mg/kg i.v.) had no effect on leukotriene-induced coronary constriction. Inhibition produced by FPL-55712 may be useful in disease states involving leukotriene-mediated coronary constriction.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP40786081 FPL-55712 FPL-55712 40786-08-1 Price
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