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Effects of Halopemide, a New Psychotropic Agent, on the Uptake of Serotonin by Blood Platelets

A J Loonen, W Soudijn

Arch Int Pharmacodyn Ther. 1979 Feb;237(2):267-74.

PMID: 39525

Abstract:

The influence of halopemide, a new psychotropic agent, and some putative metabolites on the uptake of 14C-5-HT into blood platelets of rat and man were studied and compared to the effects of imipramine, sulpiride and clozapine. Halopemide, its putative metabolites R 38570 and R 29676 and sulpiride inhibited the uptake in a dose-dependent manner, but the compounds were less active than imipramine. Clozapine and p-fluorohippuric acid, another putative metabolite of halopemide, were totally devoid of activity.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP59831651 Halopemide Halopemide 59831-65-1 Price
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