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Effects of Imperatorin in the Cardiovascular System and Cancer

Effects of Imperatorin in the Cardiovascular System and Cancer

M I Nasser, Shuoji Zhu, Haiyan Hu, Huanlei Huang, Minghui Guo, Ping Zhu

Biomed Pharmacother. 2019 Dec;120:109401.

PMID: 31622950

Abstract:

Patients with cancer survivors are at increased risk of cardiovascular disease(CVD). Cardio-oncology has developed as a new discipline with the advances in cancer treatment. There are many new challenges for the clinician and a new frontier for research and investigation. There is an urgent need for further study on the prevention of cardiovascular toxicity. Imperatorin (IMP) is a natural form of coumarin and extract from several plants with diver's pharmacokinetic effects, including antioxidant and anti-inflammatory properties. This review focus on the molecular mechanisms and pharmacological effects of Imperatorin maybe provide potential cancer and cardiovascular protection that targets IMP. Further studies are required to elucidate the entire spectrum of cytotoxic activities of these compounds to validate and expand their preclinical and clinical applications and to clarify the potential role of IMP.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP482440-B	Imperatorin		482-44-0	Price

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