Home
Resources
Publications
Effects of Injection of Gamma-Aminobutyric Acid Agonists Into the Nucleus Accumbens on Naloxone-Induced Morphine Withdrawal

Effects of Injection of Gamma-Aminobutyric Acid Agonists Into the Nucleus Accumbens on Naloxone-Induced Morphine Withdrawal

Betilay Topkara, Hasan R Yananli, Eren Sakallı, Mahluga Jafarova Demirkapu

Pharmacology. 2017;100(3-4):131-138.

PMID: 28637045

Abstract:

Aims:
This study was to investigate the effects of local administration of gamma-aminobutyric acid (GABA) agonists into the nucleus accumbens (NAc) on naloxone-induced morphine withdrawal symptoms.
Methods:
Bilateral guide cannulas were stereotaxically implanted in the shell or core regions of the NAc of Sprague-Dawley rats. After a recovery period, 3 morphine pellets, each consisting of 75 mg morphine base, were placed subcutaneously on the first and third days of the study with the rats under mild ether anaesthesia. The GABA agonists, baclofen hydrochloride or muscimol hydrobromide, were injected into the NAc, and morphine withdrawal was induced by naloxone on the fifth day.
Results:
Administration of baclofen to the shell or core regions of the NAc of Sprague-Dawley rats led to statistically significant decreases in both behavioural and locomotor activity parameters during the morphine withdrawal period, compared to the control group. However, there were no statistically significant changes in locomotor activity or withdrawal behavioural parameters, with the exception of wet dog shakes, between control and muscimol-treated groups.
Conclusion:
These findings show that GABAergic conduction in the NAc is effective on the morphine withdrawal symptoms, and that both the shell and core regions of the NAc are associated with this effect.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP18174726	Muscimol hydrobromide		18174-72-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: