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Effects of Interactions Between Progesterone and Prostaglandin on Uterine Contractility in a Perfused Swine Uterus Model

Effects of Interactions Between Progesterone and Prostaglandin on Uterine Contractility in a Perfused Swine Uterus Model

Julian Künzel, Klaudija Geisler, Theodoros Maltaris, Andreas Müller, Inge Hoffmann, Heike Schneider, Matthias W Beckmann, Ralf Dittrich, Patricia G Oppelt

In Vivo. Jul-Aug 2014;28(4):467-75.

PMID: 24982211

Abstract:

Background/aim:
Uterine quiescence at the time of embryo transfer is a prerequisite for successful in vitro fertilization (IVF). This study assessed whether prostaglandin-induced contractions in the perfused swine uterus can be reduced by progesterone.
Materials and methods:
Fifty-eight non-pregnant swine uteri were perfused using an established extracorporeal perfusion model. Intrauterine pressure changes during perfusion with prostaglandin (PG) administration (PGE1, PGE2, PGF2α) and progesterone (1 pg/ml, 10 pg/ml, 25 pg/ml, 50 pg/ml) were assessed using an intrauterine double-chip microcatheter.
Results:
The contraction-stimulating effect of PGs was clearly reduced by progesterone. Only PGE1 still triggered relevant contractions during continuous perfusion with progesterone solution, up to a concentration of 10 pg/ml. With PGE2 and PGF2α, a clear reduction of uterine contractility was observed even at at a progesterone concentration of 1 pg/ml.
Conclusion:
The extracorporal perfusion model of swine uteri shows that PG-induced contractions can be reduced in a dose-dependent manner by progesterone.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP57830-A	Progesterone solution		57-83-0	Price

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