Home
Resources
Publications
Effects of α-lipoic Acid and Eicosapentaenoic Acid in Overweight and Obese Women During Weight Loss

Effects of α-lipoic Acid and Eicosapentaenoic Acid in Overweight and Obese Women During Weight Loss

Ana E Huerta, Santiago Navas-Carretero, Pedro L Prieto-Hontoria, J Alfredo Martínez, María J Moreno-Aliaga

Obesity (Silver Spring). 2015 Feb;23(2):313-21.

PMID: 25594166

Abstract:

Objective:
To evaluate the potential body weight-lowering effects of dietary supplementation with eicosapentaenoic acid (EPA) and α-lipoic acid separately or combined in healthy overweight/obese women following a hypocaloric diet.
Methods:
This is a short-term double-blind placebo-controlled study with parallel design that lasted 10 weeks. Of the randomized participants, 97 women received the allocated treatment [Control, EPA (1.3 g/d), α-lipoic acid (0.3 g/d), and EPA+α-lipoic acid (1.3 g/d+0.3 g/d)], and 77 volunteers completed the study. All groups followed an energy-restricted diet of 30% less than total energy expenditure. Body weight, anthropometric measurements, body composition, resting energy expenditure, blood pressure, serum glucose, and insulin and lipid profile, as well as leptin and ghrelin levels, were assessed at baseline and after nutritional intervention.
Results:
Body weight loss was significantly higher (P<0.05) in those groups supplemented with α-lipoic acid. EPA supplementation significantly attenuated (P<0.001) the decrease in leptin levels that occurs during weight loss. Body weight loss improved lipid and glucose metabolism parameters but without significant differences between groups.
Conclusions:
The intervention suggests that α-lipoic acid supplementation alone or in combination with EPA may help to promote body weight loss in healthy overweight/obese women following energy-restricted diets.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1077287-B	(±)-α-Lipoic acid		1077-28-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: