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Effects of Lobetyolin, Lobetyol and Methyl Linoleate on Secretion, Production and Gene Expression of MUC5AC Mucin From Airway Epithelial Cells

Effects of Lobetyolin, Lobetyol and Methyl Linoleate on Secretion, Production and Gene Expression of MUC5AC Mucin From Airway Epithelial Cells

Yong Pill Yoon, Jiho Ryu, Su Hyun Park, Hyun Jae Lee, Seungho Lee, Sang Kook Lee, Ju-Ock Kim, Jang-Hee Hong, Jeong Ho Seok, Choong Jae Lee

Tuberc Respir Dis (Seoul). 2014 Nov;77(5):203-8.

PMID: 25473407

Abstract:

Background:
In this study, we investigated whether lobetyolin, lobetyol, and methyl linoleate derived from Codonopsis pilosula affect MUC5AC mucin secretion, production, and gene expression from airway epithelial cells.
Methods:
Confluent NCI-H292 cells were pretreated with lobetyolin, lobetyol, or methyl linoleate for 30 minutes and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 hours. The MUC5AC mucin gene expression, and mucin protein production and secretion were measured by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay, respectively.
Results:
Lobetyolin, lobetyol, and methyl linoleate inhibited the gene expression of MUC5AC mucin induced by PMA; lobetyolin did not affect PMA-induced MUC5AC mucin production. However, lobetyol and methyl linoleate inhibited the production of MUC5AC mucin; lobetyolin and lobetyol did not significantly affect PMA-induced MUC5AC mucin secretion from NCI-H292 cells. However, methyl linoleate decreased the MUC5AC mucin secretion.
Conclusion:
These results suggest that among the three compounds, methyl linoleate can regulate gene expression, production, and secretion of MUC5AC mucin by directly acting on the airway epithelial cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP112630-A	Methyl linoleate		112-63-0	Price

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