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Effects of Neonatal Administration of 17beta-estradiol, Beta-Estradiol 3-benzoate, or Bisphenol A on Mouse and Rat Spermatogenesis

Effects of Neonatal Administration of 17beta-estradiol, Beta-Estradiol 3-benzoate, or Bisphenol A on Mouse and Rat Spermatogenesis

Yoshiro Toyama, Shigeki Yuasa

Reprod Toxicol. 2004 Dec;19(2):181-8.

PMID: 15501383

Abstract:

Bisphenol A (BPA) is a global environmental contaminant that has been implicated as a potential endocrine disruptor. In the present study, newborn rats and mice were injected subcutaneously with BPA to determine the potential developmental effects on the testis. Testes were examined by light and electron microscopy at 15 weeks of age. Other groups of newborn mice and rats were injected with 17beta-estradiol (E2) or beta-estradiol 3-benzoate (E2B) in a similar manner. BPA, E2, and E2B had similar effects on testes. When treated animals reached puberty and spermiogenesis began, the first sign of the effects was detected in the steps 2-3 spermatids: the acrosomal granule and nucleus were deformed. Henceforth, abnormalities in the acrosome and nucleus were observed in older spermatids and spermatozoa. Ectoplasmic specialization between the Sertoli cell and spermatids was also affected: some specializations were partially or totally deleted. When animals fully matured, the effects of the agents were not found in the testes, and the animals were found to be fertile. The results of the present study show that BPA acts as an estrogen, and causes changes which appear to revert in adults.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP50500-A	β-Estradiol 3-benzoate		50-50-0	Price

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