Home
Resources
Publications
Effects of Nimodipine on Noise-Induced Hearing Loss

Effects of Nimodipine on Noise-Induced Hearing Loss

F A Boettcher, R K Caldwell, M A Gratton, D R White, L R Miles

Hear Res. 1998 Jul;121(1-2):139-46.

PMID: 9682816

Abstract:

The effects of nimodipine, a calcium channel blocker, on noise-induced hearing loss were examined in gerbils. Animals were implanted subcutaneously with a timed-release pellet containing either nimodipine (approximately 10 mg/kg/day) or placebo and exposed to either 102 or 107 dBA noise. Serum levels were tested in two subjects and were in the range known to protect humans from cerebral artery vasospasm and ischemia-related neurologic deficits. Nimodipine and control groups had similar amounts of noise-induced (a) permanent threshold shift; (b) reductions in distortion product otoacoustic emissions; (c) reductions in tuning and suppression of the compound action potential; and (d) loss of outer hair cells. The results suggest that nimodipine, at a dose which results in clinically relevant serum levels, does not provide protection from the effects of moderately intense noise exposures.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP70172962	Nimodipine Related Compound B		70172-96-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: