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Effects of Nimodipine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Depletions in the Biogenic Amine Levels in Mice

Effects of Nimodipine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Depletions in the Biogenic Amine Levels in Mice

M Gerlach, H Russ, J Winker, K Witzmann, J Traber, J P Stasch, P Riederer, H Przuntek

Arzneimittelforschung. 1993 Apr;43(4):413-5.

PMID: 7684224

Abstract:

In view of the calcium hypothesis the effect of nimodipine (Bay e 9736, CAS 66085-59-4) on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced depletions in dopamine and serotonin were investigated in C57-BL/6 mice. Oral treatment with nimodipine (5 mg/kg and 20 mg/kg b.i.d., respectively, for 9 days) prior to, during and following administration of MPTP appeared to attenuate MPTP-induced neurochemical changes in a dose-related manner. The results suggest that nimodipine reduces MPTP-induced damages, especially in the serotoninergic system, through its calcium antagonistic effects.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP66085594-A	Nimodipine - CAS 66085-59-4		66085-59-4	Price

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