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Effects of Ocular Administration of Ophthalmic 2% Dorzolamide Hydrochloride Solution on Aqueous Humor Flow Rate and Intraocular Pressure in Clinically Normal Cats

Effects of Ocular Administration of Ophthalmic 2% Dorzolamide Hydrochloride Solution on Aqueous Humor Flow Rate and Intraocular Pressure in Clinically Normal Cats

Amy J Rankin, William R Crumley, Rachel A Allbaugh

Am J Vet Res. 2012 Jul;73(7):1074-8.

PMID: 22738060

Abstract:

Objective:
To determine the effects of ocular administration of ophthalmic 2% dorzolamide hydrochloride solution on aqueous humor flow rate (AHFR) and intraocular pressure (IOP) in clinically normal cats.
Animals:
20 clinically normal domestic shorthair cats.
Procedures:
Following an acclimation period, IOP was measured in each eye of all cats 5 times daily for 3 days to determine baseline values. Fifteen cats received 1 drop of 2% dorzolamide solution and 5 cats received 1 drop of control solution in each eye every 8 hours for 5 days (treatment phase). The IOP of each eye was measured 5 times during each day of the treatment phase. Prior to and after the treatment phase, AHFR in both eyes of each cat was measured via fluorophotometry.
Results:
Prior to treatment, AHFR or IOP did not differ between the treatment and control groups. In dorzolamide-treated cats, mean AHFR after the treatment phase (3.47 ± 1.5 μL/min) was significantly lower than the value prior to treatment (5.90 ± 2.2 μL/min) and mean IOP during the treatment phase (11.1 ± 1.0 mm Hg) was significantly lower than the baseline mean IOP (14.9 ± 1.0 mm Hg). In the control group, IOP values did not differ before or during the treatment phase and AHFRs did not differ before and after the treatment phase.
Conclusions and clinical relevance:
Ocular administration of 2% dorzolamide solution significantly decreased AHFR and IOP in clinically normal cats. Application of 2% dorzolamide solution may be an effective treatment in cats with glaucoma.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP923013676	2,5-Dimethoxy-4-ethylphenylethylamine hydrochloride solution		923013-67-6	Price

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