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[Effects of Olprinone Hydrochloride After Coronary Artery Bypass Grafting]

[Effects of Olprinone Hydrochloride After Coronary Artery Bypass Grafting]

Takero Arai

Masui. 2004 Feb;53(2):122-30.

PMID: 15011418

Abstract:

Background:
We have examined the effect of olprinone hydrochloride on hemodynamics and peripheral circulation after cardiopulmonary bypass (CPB) in 56 patients who underwent coronary artery bypass grfting.
Methods:
The subjects were randomly classified into 2 groups: B-group of 25 patients who received bolus plus continuous administration of olprinone hydrochloride and control group without administration of olprinone hydrochloride (C-group) of 31 patients. In the B-group, after de-clamping of the aortic occlusion, olprinone hydrochloride 15 micrograms.kg-1 bolus was administered and followed by continuous administration at 0.1 microgram.kg-1.min-1.
Results:
We excluded six cases in C-group in whom it was not possible to maintain blood pressure without olprinone hydrochloride. In the B-group, peripheral temperature was kept significantly higher and blood lactic acid value was kept significantly lower until 6 hours after the operation compared with C-group. In the B-group, cardiac index was kept significantly higher for a long period of time, and dosage of concomitantly used catecholamine could be significantly reduced.
Conclusions:
Olprinone increased CI and decreased SVRI, and it led to easy weaning from CPB, providing excellent hemodynamics after CABG. These results suggest that olprinone hydrochloride 15 micrograms.kg-1 bolus plus 0.1 microgram.kg-1.min-1 continuous administration may be effective for improvement of hemodynamics and peripheral circulation after CPB.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP119615633	Olprinone hydrochloride		119615-63-3	Price

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