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[Effects of Olprinone Hydrochloride on Intraocular Pressure and Ocular Blood Flow in Patients After Cardiac Surgery Under Cardiopulmonary Bypass]

[Effects of Olprinone Hydrochloride on Intraocular Pressure and Ocular Blood Flow in Patients After Cardiac Surgery Under Cardiopulmonary Bypass]

Koji Goto, Akira Hasegawa, Chihiro Shingu, Yoshio Hayano, Shigenori Yoshitake, Takayuki Noguchi

Masui. 2002 Nov;51(11):1212-6.

PMID: 12481446

Abstract:

Background:
We evaluated the effect of olprinone hydrochloride on intraocular pressure (IOP) and ocular blood flow in patients after cardiac surgery under cardiopulmonary bypass (CPB).
Methods:
Nine patients after cardiac surgery under CPB were investigated. We measured IOP of the left eye using tonometer (Tonopen XL, BIO RAD, Osaka), and mean blood flow velocity in the left ophthalmic artery (Vm) and calculated the pulsatility index in the left ophthalmic artery (PI) using 2 MHz Doppler ultrasound system (Multidop P, DWL, Germany). After baseline measurement, the olprinone hydrochloride loading dosage was increased from 0.15 to 0.3 microgram.kg-1.min-1 every 60 minutes. The intraocular pressure and ocular blood flow were measured at each point.
Results:
IOP and PI decreased significantly, and Vm increased significantly at the infusion rate of 0.3 microgram.kg-1.min-1 from baseline. There was a significant linear correlations between IOP and Vm.
Conclusion:
We demonstrated that olprinone hydrochloride led to a decrease in IOP and an increase in ocular blood flow in patients after cardiac surgery under CPB.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP119615633	Olprinone hydrochloride		119615-63-3	Price

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