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Effects of Palladium Nanoparticles on the Cytokine Release From Peripheral Blood Mononuclear Cells of Palladium-Sensitized Women

Effects of Palladium Nanoparticles on the Cytokine Release From Peripheral Blood Mononuclear Cells of Palladium-Sensitized Women

Marcella Reale, Giovina Vianale, Lavinia Vittoria Lotti, Renato Mariani-Costantini, Silvia Perconti, Antonio Cristaudo, Kerstin Leopold, Andrea Antonucci, Luca Di Giampaolo, Ivo Iavicoli, Mario Di Gioacchino, etc.

J Occup Environ Med. 2011 Sep;53(9):1054-60.

PMID: 21866053

Abstract:

Objective:
To investigate the effects of palladium (Pd) nanoparticles on cytokine release from peripheral blood mononuclear cells (PBMCs) of control or Pd-sensitized nonatopic women.
Methods:
TNF-α, IL-5, IL-10 and IFN-γ release and/or expression from PBMCs incubated in presence of 5 to 10 nm Pd nanoparticles or Pd salt (potassium hexachloropalladate) were determined by enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction analysis. Transmission electronmicroscopy was performed.
Results:
In lipopolysaccharide-stimulated PBMCs from controls, Pd salt inhibited IFN-γ and IL-10 release, whereas Pd nanoparticles enhanced IFN-γ release and inhibited TNF-α secretion. In lipopolysaccharide-stimulated PBMCs from Pd-sensitized women showing high IFN-γ release, Pd nanoparticles inhibited TNF-α release and Pd salt IL-10 release. TNF-α and IFN-γ release and messenger RNA expression were correlated. Transmission electronmicroscopy demonstrated uptake of nanoparticles in the endocytic compartment and activation of autophagy.
Conclusions:
Palladium ions and nanoparticles exert different effects in vitro on the expression and release of cytokines.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP16919736	Potassium hexachloropalladate(IV)		16919-73-6	Price

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