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Effects of Pirimiphos-Methyl (An Organophosphate Insecticide) on the Fertility of Adult Male Rats

Effects of Pirimiphos-Methyl (An Organophosphate Insecticide) on the Fertility of Adult Male Rats

Ferdinand Ngoula, Pierre Watcho, Marie-Chantal Dongmo, Augustave Kenfack, Pierre Kamtchouing, Joseph Tchoumboué

Afr Health Sci. 2007 Mar;7(1):3-9.

PMID: 17604518

Abstract:

Background:
Organophosphate insecticides represent one of the most widely used classes of pesticides with high potential for human exposure in both rural and residential environments.
Objective:
In the present study, we investigated the effects of pirimiphos-methyl (0, 2-diethylamino-6-methylpirimidin-4-yl O, O-dimethyl phosphorothioate), an organophosphothioate pesticide, on male rat reproductive performances.
Methods:
A total of 24 adult Wistar rats were divided into 4 groups of 6 animals each and orally treated with 0, 41.67, 62.5 or 125 mg/kg of pirimiphos-methyl for 90 days.
Results:
Results from the study showed a significant increase (p<0.05) in feed consumption, body weight gain, relative testis and epidiydimis weights and intra-testicular cholesterol level in rats receiving the test substance at doses of 62.5 or 125 mg/kg whereas a significant decrease (p<0.05) in serum total protein, sperm density and motility, fertility and parturition indices and pups sex-ratio (M/F) was recorded in animals treated with 125 mg/Kg of pirimiphos methyl. Histological findings also indicated enlargement of interstitial space, inhibition of spermatogenesis, rarefaction of Leydig cells and oedema in testes compared to control animals.
Conclusion:
It could then be concluded that pirimiphos-methyl (62.5 and 125 mg/kg) is detrimental to the reproductive potentials of male rats.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS353681	Pirimiphos-methyl-(O,O-dimethyl-d6)			Price

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