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Effects of Presenilin N-terminal Fragments on Production of Amyloid Beta Peptide and Accumulation of Endogenous Presenilins

Effects of Presenilin N-terminal Fragments on Production of Amyloid Beta Peptide and Accumulation of Endogenous Presenilins

K Shirotani, K Takahashi, T Tabira

Neurosci Lett. 1999 Feb 26;262(1):37-40.

PMID: 10076867

Abstract:

To clarify the effects of the proteolytic cleavage of presenilin 1 (PS1) and presenilin 2 (PS2) proteins on their functions, we established stable cell lines which expressed the physiologically cleaved N-terminal fragment (NTF) with or without mutations of familial Alzheimer's disease (FAD). We found that exogenous expression of the PS1-NTF or PS2-NTF harboring FAD mutations was insufficient for increased production of amyloidogenic A beta X-42 peptide and that the overexpressed NTFs had no effect on the accumulation of endogenous presenilin fragments.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248117	Presenilin-1 N-Terminal Peptide			Price

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