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Effects of Propolis Flavonoids on Virus Infectivity and Replication

Effects of Propolis Flavonoids on Virus Infectivity and Replication

M Debiaggi, F Tateo, L Pagani, M Luini, E Romero

Microbiologica. 1990 Jul;13(3):207-13.

PMID: 2125682

Abstract:

The effect of five propolis flavonoids on the infectivity and replication of some herpesvirus, adenovirus, coronavirus and rotavirus strains has been studied. Experiments were performed in vitro in cell cultures using the viral plaque reduction technique. The cytotoxicity of flavonoids, including chrysine, kaempferol, acacetin, galangin and quercetin, was evaluated on uninfected monolayers to determine their effect on cell growth and viability. Chrysine and kaempferol caused a concentration-dependent reduction of intracellular replication of herpes-virus strains when monolayers were infected and subsequently cultured in a drug-containing medium. However, virus infectivity was not significantly affected. Acacetin and galangin had no effect on either the infectivity or replication of any of the viruses studied. Quercetin reduced infectivity and intracellular replication, but only at the highest concentrations tested.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP480444-A	Acacetin		480-44-4	Price
AP548834	Galangin		548-83-4	Price

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