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Effects of Prostaglandin Antagonist SC-19220 on Body Temperature and on Hyperthermic Responses to Prostaglandin E-1 and Leukocytic Pyrogen in the Cat

W G Clark, H R Cumby

Prostaglandins. 1975 Mar;9(3):361-8.

PMID: 1138292

Abstract:

Intravenous injection of SC-19220 (3-9 mg/kg) caused dose-related hypothermic responses in cats. Repeated administration of SC-19220 resulted in tolerance to its hypothermic action. During SC-19220-induced hypothermia, the hyperthermic activity of both prostaglandin E-1 and leukocytic pyrogen was reduced or abolished. Neither prostaglandin E-1 nor leukocytic pyrogen was antagonized when given shortly after recovery from SC-19220-induced hypothermia or by doses of SC-19220 which did not cause hypothermia. Although these results may indicate a role of prostaglandins in normal physiological thermoregulation, it is also possible that production of hypothermia by SC-19220 is unrelated to prostaglandin antagonism.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP19395870 SC 19220 SC 19220 19395-87-0 Price
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