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Effects of Sinensetin on Lipid Metabolism in Mature 3T3-L1 Adipocytes

Effects of Sinensetin on Lipid Metabolism in Mature 3T3-L1 Adipocytes

Seong-Il Kang, Hye-Sun Shin, Hee-Chul Ko, Se-Jae Kim

Phytother Res. 2013 Jan;27(1):131-4.

PMID: 22438091

Abstract:

Sinensetin is a rare polymethoxylated flavone found in certain citrus fruits. In this study, we investigated the effects of sinensetin on lipid metabolism in mature 3T3-L1 adipocytes. Sinensetin decreased the expression of sterol regulatory element-binding protein 1c (SREBP1c), suggesting its antiadipogeneic property via downreguation of SREBP1c. Also, sinensetin increased the phosphorylation of protein kinase A and hormone-sensitive lipase, indicating its lipolytic property via a cAMP-mediated signaling pathway. Moreover, sinensetin inhibited insulin-stimulated glucose uptake by decreasing the phosphorylation of insulin receptor substrate and Akt. Furthermore, sinensetin increased the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase. It also upregulated mRNA expression of carnitine palmitoyltransferase-1a, suggesting that sinensetin enhances fatty acid β-oxidation through the AMPK pathway. Taken together, these results suggest that sinensetin may have potential as a natural agent for prevention/improvement of obesity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2306276	Sinensetin		2306-27-6	Price

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