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Effects of Sub-Acute Exposure to Rhodium (As Rh (III) Chloride Hydrate) on Cytokines in Female Wistar Rats

Ivo Iavicoli, Alessandro Sgambato, Luca Fontana, Alessandro Marinaccio, Veruscka Leso, Maddalena Corbi, Antonio Bergamaschi, Edward J Calabrese

Bull Environ Contam Toxicol. 2012 Sep;89(3):686-92.

PMID: 22885547

Abstract:

Quantitative changes in different cytokines were determined in serum of female Wistar rats exposed to Rhodium (III) chloride hydrate to evaluate its early effects on the immune system. Findings revealed an inhibitory effect of Rh salt since each cytokine, with the exceptions of IL-1α and IL-2 levels observed at the highest doses of exposure, was reduced compared to the controls and interestingly, the lowest doses induced the greatest inhibition. This generalized decrease of cytokine levels was not related to a specific cytokine pathway, and may suggest an anti-inflammatory role of Rh salt.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP20765984 Rhodium(III) chloride hydrate Rhodium(III) chloride hydrate 20765-98-4 Price
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