Home
Resources
Publications
Effects of Synthetic Human Gastrin-Releasing Peptide on Pancreatic Exocrine Secretion and Release of Pancreatic Polypeptide in Conscious Rats

Effects of Synthetic Human Gastrin-Releasing Peptide on Pancreatic Exocrine Secretion and Release of Pancreatic Polypeptide in Conscious Rats

K Miyasaka, K Miyazaki, A Funakoshi, K Kitani, H Yajima

Int J Pancreatol. 1989 Apr;4(3):251-60.

PMID: 2760512

Abstract:

The effects of a newly synthesized peptide, human gastrin-releasing peptide (hGRP), on the pancreatic exocrine secretion and the release of pancreatic polypeptide (PP) were examined in the conscious rat. Plasma PP concentrations were determined by a recently established specific radioimmunoassay for rat PP. Amounts of 0.18, 0.35, and 3.5 nmol/kg/h hGRP significantly stimulated both pancreatic exocrine secretion and 0.35 nmol/kg/h of hGRP increased PP release. Simultaneously infused proglumide (300 mg/kg/h) did not affect either pancreatic exocrine secretion or PP release. However, simultaneous infusion of atropine (100 micrograms/kg/h) slightly inhibited PP release, but did not restrict the incremental response of pancreatic protein secretion to hGRP. These results suggest that hGRP directly stimulates pancreatic exocrine secretion and PP release.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP93755852	Gastrin Releasing Peptide human		93755-85-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: