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Effects of the Tropical Ginger compound,1'-acetoxychavicol Acetate, Against Tumor Promotion in K5.Stat3C Transgenic Mice

Effects of the Tropical Ginger compound,1'-acetoxychavicol Acetate, Against Tumor Promotion in K5.Stat3C Transgenic Mice

Vinita Batra, Zanobia Syed, Jennifer N Gill, Malari A Coburn, Patrick Adegboyega, John DiGiovanni, J Michael Mathis, Runhua Shi, John L Clifford, Heather E Kleiner-Hancock

J Exp Clin Cancer Res. 2012 Jun 15;31(1):57.

PMID: 22704648

Abstract:

The purpose of the current study was to determine whether a tropical ginger derived compound 1'-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were effective at suppressing p-Tyr705Stat3 expression. However, ACA and FA showed promising inhibitory effects against skin tumorigenesis in K5.Stat3C mice. ACA also suppressed phospho-p65 NF-κB activation, suggesting a potential mechanism for its action.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP52946222	1′-Acetoxychavicol acetate		52946-22-2	Price

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