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Effects of Trisodium Nitrilotriacetate Monohydrate, Nitrilotriacetic Acid and Ammonium Chloride on Urinary Bladder Carcinogenesis in Rats Pretreated With N-bis(2-hydroxypropyl) Nitrosamine

Effects of Trisodium Nitrilotriacetate Monohydrate, Nitrilotriacetic Acid and Ammonium Chloride on Urinary Bladder Carcinogenesis in Rats Pretreated With N-bis(2-hydroxypropyl) Nitrosamine

Y Kitahori, T Shimoyama, M Ohshima, H Matsuki, H Hashimoto, S Minami, N Konishi, Y Hiasa

Cancer Lett. 1988 Dec 1;43(1-2):105-10.

PMID: 3203320

Abstract:

The effects of trisodium nitrilotriacetate monohydrate (Na3 NTA.H2O) nitrilotriacetic acid (H3NTA) and ammonium chloride (NH4Cl) on two-stage urinary bladder carcinogenesis were examined. Carcinogenesis was initiated by administration of 0.2% N-bis (2-hydroxypropyl)-nitrosamine (DHPN) to male Wistar rats in the drinking water for 2 weeks, and then the animals were treated with basal diet containing Na3NTA.H2O, Na3NTA.H2O plus NH4Cl, H3NTA, H3NTA plus NH4Cl, or without these chemicals for 28 weeks. Na3NTA.H2O increased significantly the resultant incidence of neoplastic and preneoplastic lesions of the urinary bladder. Moreover, treatment with Na3NTA.H2O, without the initiation, itself induced papillary or nodular (PN)-hyperplasia. H3NTA produced only a slight increase in the incidence of preneoplastic urinary bladder lesions (PN-hyperplasia) in rats initiated by DHPN, and this was not statistically significant. Elevation of both pH and sodium ion concentration in the urine were correlated with promotion of tumor development. These data showed that Na3NTA.H2O was more effective than H3NTA with regard to promoting potential, and that changes in both urinary pH and concentration of sodium played important roles in enhancement of urinary bladder tumorigenesis by these chemicals.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS777113	(12-Dodecylphosphonic acid)N,N-Dimethyl-N-octadecyl ammonium chloride			Price

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