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[Efficacy and Safety of 3% Mepivacaine Hydrochloride Injection for Oral Local Anesthesia]

[Efficacy and Safety of 3% Mepivacaine Hydrochloride Injection for Oral Local Anesthesia]

Sheng Ding, Ya-Qin Zhu, Ying-Na Wu, Dong Cao

Shanghai Kou Qiang Yi Xue. 2008 Jun;17(3):328-31.

PMID: 18661082

Abstract:

Purpose:
To assess the efficacy and safety of 3% mepivacaine hydrochloride injection for oral local anesthesia.
Methods:
68 non-hypertension patients and 36 hypertension patients were randomly divided into 2 groups for local anesthesia. 2% lidocaine with adrenaline in same cartridge was as control group and 3% mepivacaine was as the experimental group. The onset time,duration and pain-free time of 2 anaesthetics were examined. The blood pressure and heart rate change, neural reaction and side effect of 2 groups were observed. SAS software package was used for statistical analysis.
Results:
In the mepivacaine group, the average onset time was 111s, the duration time was 212s and pain-free time was 134 min ,which was similar to those of 2% lidocaine. Immediately after injection, 5 minutes and 10 minutes after injection of anesthesia, and post-operation, there were no significant changes in the systolic blood pressures between 2% lidocaine group and 3% mepivacaine group (P>0.05), but there were significant changes in diastolic blood pressures and heart rate (P<0.05).
Conclusion:
3% mepivacaine has quick onset, ideal anesthetic effect and little side effect on cardiovascular system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1722629-B	(±)-Mepivacaine hydrochloride		1722-62-9	Price

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