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Efficacy and Safety Profile of Doxofylline Compared to Theophylline in Asthma: A Meta-Analysis

Efficacy and Safety Profile of Doxofylline Compared to Theophylline in Asthma: A Meta-Analysis

Paola Rogliani, Luigino Calzetta, Josuel Ora, Mario Cazzola, Maria Gabriella Matera

Multidiscip Respir Med. 2019 Aug 3;14:25.

PMID: 31388422

Abstract:

Background:
Oral methylxanthines are effective drugs for the treatment of chronic obstructive respiratory disorders. The novel methylxanthine doxofylline, that has bronchodilator and anti-inflammatory activities, is not affected by the major drawback of theophylline. Nowadays large-scale quantitative synthesis comparing the efficacy and safety profile of doxofylline vs. theophylline in the treatment of asthma is still lacking. Therefore, we performed a quantitative synthesis to compare the efficacy/safety profile of doxofylline and theophylline in asthma.
Methods:
A pairwise and network meta-analyses were performed to assess the impact of doxofylline vs. theophylline and placebo on the change in asthma events, risk of adverse events (AEs), forced expiratory volume in 1 s (FEV1), and salbutamol use.
Results:
Data obtained from 696 asthmatic patients were extracted from 4 randomized controlled trials published between 2015 and 2018. Doxofylline was significantly (P < 0.05) more effective than theophylline in reducing the daily asthma events (mean difference - 0.14, 95%CI -0.27 - 0.00) and risk of AEs (relative risk 0.76, 95%CI 0.59-0.99). Doxofylline was as effective as theophylline in improving FEV1, and a trend of superiority (P = 0.058) was detected for doxofylline over theophylline with respect to the reduction in the use of salbutamol as rescue medication. The rank of effectiveness was doxofylline>theophylline> > placebo, and the rank of safety was placebo>doxofylline> > theophylline.
Conclusions:
Doxofylline is an effective and safe methylxanthine for the treatment of asthma, with an efficacy/safety profile greater than that of theophylline.
Trial registration:
Meta-analysis registration: CRD42019119849.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP69975866	Doxofylline		69975-86-6	Price

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