Home
Resources
Publications
Efficacy of Bromfenac Sodium Ophthalmic Solution for Treatment of Dry Eye Disease

Efficacy of Bromfenac Sodium Ophthalmic Solution for Treatment of Dry Eye Disease

Hiroshi Fujishima, Miki Fuseya, Masarou Ogata, Dogru Murat

Asia Pac J Ophthalmol (Phila). Jan-Feb 2015;4(1):9-13.

PMID: 26068607

Abstract:

Purpose:
To evaluate the efficacy of bromfenac sodium ophthalmic solution (BF) in patients with dry eye disease (DED) inadequately controlled by monotherapy with artificial tears (ATs).
Design:
An investigator-oriented trial with a single-arm, nonrandomized, open-label design.
Methods:
Twenty-six patients, who showed no symptomatic improvement of DED after 1 month of AT treatment, were enrolled. Bromfenac sodium ophthalmic solution was administered adjunctively with AT for 1 month. The BF treatment was then discontinued, and AT treatment alone was continued for 3 months. The signs and symptoms were evaluated at the beginning of BF treatment (Pre), at the end of the combined BF and AT treatment (BF1M), and at 1 and 3 months after discontinuation of BF treatment (Po1M and Po3M, respectively).
Results:
The dryness scores at BF1M were significantly improved compared with Pre (P < 0.001) and significantly superior to Po3M (P < 0.001). No significant changes in the Schirmer scores were observed throughout the treatment period. The tear film breakup time was significantly improved at BF1M (4.4 ± 2.3 seconds) compared with Pre (2.8 ± 1.8 seconds; P < 0.001). Superficial punctate keratopathy showed significant improvements in the total score of area and density at BF1M compared with Pre (P < 0.001). However, these parameters had significantly worsened at Po3M compared with BF1M. No adverse events were observed.
Conclusions:
Bromfenac sodium ophthalmic solution has improved the dryness of the eye and signs of DED through its anti-inflammatory effects. Nonsteroidal anti-inflammatory drugs were suitable as anti-inflammatory ophthalmic solutions for patients with DED.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP91714931	Bromfenac sodium		91714-93-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: