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Efficacy of Eosin B as a New Antimalarial Drug in a Murine Model

Efficacy of Eosin B as a New Antimalarial Drug in a Murine Model

Zahra Zamani, Alireza Sadeghi Tafreshi, Hossein Nahrevanian, Behzad Lame-Rad, Fatemeh Pourfallah, Hossein Eslamifar, Sedigheh Sadeghi, Farideh Vahabi, Ayda Iravani, Mohammad Arjmand

Malar Res Treat. 2012;2012:381724.

PMID: 23365788

Abstract:

The initial success of any adopted anti-infective strategy to malaria is followed by a descent due to the emergence of resistance to it. The search for new drugs and drug targets is a consistent demand in this disease. Eosin B, a common laboratory dye, is reported to have good antiparasitic properties in vitro. It was studied for its antiparasitic effect in vivo on chloroquine-sensitive Plasmodium berghei murine malaria. Eosin B was administered in 2 different doses by either the oral or parenteral route, once or twice daily to mice infected with Plasmodium berghei. Both the doses of eosin B 400 mg/kg and 800 mg/kg gave better results than the controls which were 40 mg/kg chloroquine and 100 mg/kg of arteether with P < 0.005 significance. Percentage suppressive activity by Peter's test of eosin B was better, though at a higher dose than both the controls. Survival rate of mice receiving the higher dose of eosin B was longer than that of the controls. When administered twice daily, the mice were fully cured after 4 days. Eosin B seems to be a promising drug exhibiting good antimalarial effects in the murine model of the disease.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP548243	Eosin B		548-24-3	Price

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