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Efficacy of Glycerol and Flax Seed Oil as Anti-Adhesive Barriers After Thyroidectomy

Efficacy of Glycerol and Flax Seed Oil as Anti-Adhesive Barriers After Thyroidectomy

Oguz Idiz, Erhan Aysan, Deniz Firat, Yeliz Emine Ersoy, Merve Busra Cengiz, Huseyin Akbulut, Arda Isık, Mahmut Muslumanoglu

Med Sci Monit. 2014 Jun 28;20:1090-4.

PMID: 24973306

Abstract:

Background:
We evaluated the effects of local flax seed oil and glycerol application for reducing adhesion formation after thyroidectomy.
Material and methods:
We randomly assigned 18 female Wistar albino rats (median weight: 275 g, median age: 4.5 mth) to 3 groups: 0.1 ml 0.9% NaCl, glycerol, and flax seed oil were sprayed in a perithyroidal area after thyroidectomy operation on all animals as anti-adhesive barriers. Rats were sacrificed on the postoperative 14th day and adhesions were evaluated macroscopically and microscopically.
Results:
The median macroscopic adhesion score was 3.0±0.0 in the 0.9% NaCl group, 1.33±0.52 in the glycerol group, and 1.67±0.53 in the flax seed oil group. The median histopathological fibrosis scores were 2.33±0.82, 0.67±0.52, and 0.83±0.75, respectively. Both glycerol and flaxseed oil group macroscopic and microscopic scores were significantly lower than the 0.9% NaCl group (p<0.05). There was no significant difference among the groups (p>0.05).
Conclusions:
Glycerol and flax seed oil both decrease the incidence of post-thyroidectomy adhesion in rats, but glycerol is more effective.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP8001261	Flax seed oil		8001-26-1	Price

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