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[Efficacy of Midodrine Hydrochloride in the Treatment of Children With Vasovagal Syncope]

[Efficacy of Midodrine Hydrochloride in the Treatment of Children With Vasovagal Syncope]

Xiao-Yan Liu, Cheng Wang, Li-Jia Wu, Chun-Yan Hu, Ping Lin, Ming-Xiang Li, Xiao-Li Cui, Zhen-Wu Xie

Zhonghua Yi Xue Za Zhi. 2009 Jul 28;89(28):1951-4.

PMID: 19950567

Abstract:

Objective:
To explore the efficacy of midodrine hydrochloride in the treatment of vasovagal syncope (VVS) in children.
Methods:
Forty-eight children with unexplained syncope and prodromata (21 males, 27 females, aged 6 -17 years, mean 11 years +/- 3 years) were randomly assigned into 3 groups. They were health education group, cresol group and midodrine hydrochloride group respectively. Cresol group was comprised of children given cresol as first-line therapy in addition to health education and midodrine hydrochloride group patients given midodrine hydrochloride on the basis of cresol group. Repeated head-up tilt testing (HUTT) and follow-ups of at least 6 months were conducted to evaluate the therapeutic efficacy, side effects of midodrine hydrochloride and hemodynamic changes in treating pediatric VVS.
Results:
(1) The HUTT-based effective rate of 3 group was 20.0% (2/10), 60.9% (14/23) and 80.0% (12/15) respectively. It was significantly higher in cases of midodrine hydrochloride group and cresol group than that of health education group (P < 0.05). However,there was no significant difference in the HUTT-based effective rate between cresol group and midodrine hydrochloride group (P > 0.05). (2) During the follow-up period, the recurrence rate of syncope was significantly lower in midodrine hydrochloride group than in other two groups (P < 0.05). However, there was no significant difference in the recurrence rate of syncope between health education and cresol groups (P > 0.05). (3) There was no statistic difference in supine hemodynamic indices (HR, SBP, DBP) between before and after treatment in 3 groups. After midodrine therapy, the effects of midodrine upon changes in systolic and diastolic pressures and heart rate, between upright beginning and supine positions, were statistically significant (P <0.05).
Conclusion:
Health education and cresol are conventional therapies for pediatric VVS. The efficacy can be enhanced by supplementing midodrine hydrochloride. Such a regimen is effective and safe in treating pediatric VVS.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3092179	Midodrine hydrochloride		3092-17-9	Price

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