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Efficacy of the D- And L-isomers of N-acetylmethionine for Chicks Fed Diets Containing Either Crystalline Amino Acids or Intact Protein

Efficacy of the D- And L-isomers of N-acetylmethionine for Chicks Fed Diets Containing Either Crystalline Amino Acids or Intact Protein

D H Baker

J Nutr. 1979 Jun;109(6):970-4.

PMID: 448454

Abstract:

Chick growth assays were used to evaluate the efficacy and toxicity of the L- and D-isomers of N-acetylmethionine when fed as a source of methionine in crystalline amino acid diets. In agreement with earlier rat studies employing intact protein diets, N-acetyl-L-methionine had a methionine-sparing value of 100% and N-acetyl-D-methionine a value of zero. The former was also observed to be fully effective as a methionine supplement when added to a methionine-deficient diet containing equal protein contributions from soybean, casein and gelatin. Isosulfurous levels of excess L-methionine or N-acetyl-L-methionine were equally growth depressing, but L-methionine elevated spleen iron deposition to a greater extent than N-acetyl-L-methionine. N-acetyl-D-methionine in excess depressed growth only slightly, due entirely to a depression in voluntary food intake, and no evidence of splenic hemosiderosis was observed from this addition.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1115475	N-Acetyl-D,L-Methionine		1115-47-5	Price

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