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Efficiency of Cardioplegic Solutions Containing L-arginine and L-aspartic Acid

Efficiency of Cardioplegic Solutions Containing L-arginine and L-aspartic Acid

O I Pisarenko, V S Shul'zhenko, I M Studneva

Bull Exp Biol Med. 2006 Apr;141(4):410-3.

PMID: 17152357

Abstract:

In experiments on rats we studied the effects of cardioplegic solutions with L-aspartic acid or L-arginine on functional recovery and metabolism of isolated working heart after 40-min normothermal global ischemia and 30-min reperfusion. After reperfusion of the hearts preventively protected with cardioplegic solution containing L-aspartic acid or L-arginine, coronary flow decreased in comparison with the initial values. As a component of cardioplegic solution, L-arginine was less efficient in recovery of contractility and cardiac output of the hearts in comparison with L-aspartic acid. In hearts protected with L-aspartic acid, the postischemic levels of ATP and phosphocreatine were significantly higher, and the level of lactate was significantly lower than in hearts protected with L-arginine. In comparison with L-arginine, L-aspartic acid is a more efficient component of cardioplegic solution in protection of the heart from metabolic and functional damages caused by global ischemia and reperfusion.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP81201981	L-Aspartic acid-4-13C		81201-98-1	Price

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