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Efficient Cleavage of DS DNA by Bleomycin Conjugated via Hexaethylene Glycol Linker to Triplex-Forming Oligonucleotides

Pavel Vorobjev, Olessia Tchaika, Valentina Zarytova

Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(6-7):1047-51.

PMID: 15560101

Abstract:

New conjugates of bleomycin A5 with oligonucleotides are synthesized. The bleomycin residue was attached to the 3'- or 5'- terminus of hexadecathymidilate via a hexaethylene glycol phosphate linker. Newly designed conjugates were shown to cleave site-specifically both strands of a dsDNA fragment within a triplex. The maximum extent of cleavage for individual strand amounts to 61%.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP2615158 Hexaethylene glycol Hexaethylene glycol 2615-15-8 Price
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