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Efficient Preparation of Incensole and Incensole Acetate, and Quantification of These Bioactive Diterpenes in Boswellia Papyrifera by a RP-DAD-HPLC Method

Michael Paul, Johann Jauch

Nat Prod Commun. 2012 Mar;7(3):283-8.

PMID: 22545396

Abstract:

Incensole and incensole acetate, found in incense, are encouraging potent bioactive diterpenic cembrenoids, inhibiting Nuclear Factor-kappaB activation. Furthermore, incensole acetate elicits psycho-activity in mice by activating the TRPV3 channels in the brain. Starting from crude extracts of the incense species Boswellia papyrifera Hochst., a convenient procedure for the efficient large-scale synthesis of incensole and its acetate is presented. Additionally, a reversed-phase, diode-array-detection, high-performance liquid chromatography (RP-DAD-HPLC) method for the quantification of incensole and incensole acetate is reported, indicating that these two compounds are typical biomarkers for B. papyrifera.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP34701536 Incensole acetate Incensole acetate 34701-53-6 Price
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