0

Efficient Synthesis of α- And δ-carbolines by Sequential Pd-catalyzed Site-Selective C-C and Twofold C-N Coupling Reactions

Tran Quang Hung, Tuan Thanh Dang, Julia Janke, Alexander Villinger, Peter Langer

Org Biomol Chem. 2015 Feb 7;13(5):1375-86.

PMID: 25464277

Abstract:

Two concise and efficient approaches were developed for the synthesis of α- and δ-carboline derivatives. The success of the synthesis relies on site-selective Suzuki-Miyaura reactions of 1-chloro-2-bromopyridine or 2,3-dibromopyridine with 2-bromophenylboronic acid and subsequent cyclization with amines which proceeds by twofold Pd-catalyzed C-N coupling reactions.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP244205401 2-Bromophenylboronic acid 2-Bromophenylboronic acid 244205-40-1 Price
qrcode