Home
Resources
Publications
Efficient Synthesis of Deuterium Labeled Hydroxyzine and Aripiprazole

Efficient Synthesis of Deuterium Labeled Hydroxyzine and Aripiprazole

Mohit Vohra, Mahendra Sandbhor, Andrew Wozniak

J Labelled Comp Radiopharm. 2015 Jun 15;58(7):304-7.

PMID: 26011470

Abstract:

Hydroxyzine and aripiprazole are active pharmaceutical ingredients that have been largely acknowledged for their antipsychotic properties. Deuterium labeled isotopes of hydroxyzine and aripiprazole are internal standards that can aid in the further research of non-isotopic forms via quantification analysis using HPLC-MS/MS. The synthesis of hydroxyzine-d8 was accomplished by coupling piperazine-d8 with 4-chlorobenzhydryl chloride followed by the reaction of the first intermediate with 2-(2-chloroethoxy) ethanol to afford 11.7% of hydroxyzine-d8 with 99.5% purity. The synthesis of aripiprazole-d8 was also achieved in two steps. 1,4-Dibromobutane-d8 reacted with 7-hydroxy-3,4-dihydro-2(1H)-quinolinone. The first intermediate was then coupled with 1-(2, 3-dichlorophenyl)piperazine hydrochloride to produce 33.4% of aripiprazole-d8 with 99.93% purity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP300543560	Chlorobenzhydryl Piperazine		300543-56-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: