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EG-VEGF: A Key Endocrine Factor in Placental Development

EG-VEGF: A Key Endocrine Factor in Placental Development

Sophie Brouillet, Pascale Hoffmann, Jean-Jacques Feige, Nadia Alfaidy

Trends Endocrinol Metab. 2012 Oct;23(10):501-8.

PMID: 22709436

Abstract:

Endocrine gland-derived vascular endothelial growth factor (EG-VEGF), also named prokineticin 1, is the canonical member of the prokineticin family. Numerous reports suggest a direct involvement of this peptide in normal and pathological reproductive processes. Recent advances propose EG-VEGF as a key endocrine factor that controls many aspects of placental development and suggest its involvement in the development of preeclampsia (PE), the most threatening pathology of human pregnancy. This review describes the finely tuned action and regulation of EG-VEGF throughout human pregnancy, argues for its clinical relevance as a potential diagnostic marker of the onset of PE, and discusses future research directions for therapeutic targeting of EG-VEGF.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413764	EG-VEGF human			Price

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