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EGF-receptor Signaling and Epithelial-Mesenchymal Transition in Human Carcinomas

EGF-receptor Signaling and Epithelial-Mesenchymal Transition in Human Carcinomas

Ala-Eddin Al Moustafa, Amal Achkhar, Amber Yasmeen

Front Biosci (Schol Ed). 2012 Jan 1;4:671-84.

PMID: 22202084

Abstract:

The epidermal growth factor receptor (EGF-R) signaling pathway maintains a balance between cell proliferation, differentiation and apoptosis, and thus it is believed that EGF-R signaling pathways play an important role in the development and progression of several human carcinomas. Epithelial-mesenchymal transition (EMT) describes the dedifferentiation switch between polarized epithelial cancer cells and contractile and motile mesenchymal (invasive) cells during cancer progression and metastasis. Activation of EGF-R signaling regulates EMT-associated invasion and migration in normal and malignant epithelial cells. In contrast, blocking EGF-R and consequently its pathways, by a monoclonal antibody (mAb) or a tyrosine kinase inhibitor (TKI), inhibit cellular migration and invasion, suggesting an essential role for EGF-R inhibitors in the control of cancer metastasis. The purpose of this review is to summarize current information regarding the role of EGF-R signaling on EMT during human cancer progression and metastasis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248768	EGF-receptor human			Price

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