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Eight Flavonoids and Their Potential as Inhibitors of Human Cytomegalovirus Replication

Eight Flavonoids and Their Potential as Inhibitors of Human Cytomegalovirus Replication

Sébastien Cotin, Claude-Alain Calliste, Marie-Christine Mazeron, Sébastien Hantz, Jean-Luc Duroux, William D Rawlinson, Marie-Cécile Ploy, Sophie Alain

Antiviral Res. 2012 Nov;96(2):181-6.

PMID: 23000494

Abstract:

The drugs currently available for treatment of severe human cytomegalovirus (HCMV) infections suffer from many drawbacks, particularly toxicity, and potential teratogenicity contraindicating their use in target populations such as pregnant women. The emergence of drug-resistant strains is still a problem for disease management, particularly in immunosuppressed populations where antivirals are used for extended periods of time. The flavonoid family of drugs contains promising candidates as they have low toxicity and inhibit different targets to currently available antivirals. We report here that, unlike their chalcon homologs, four flavonoids (baicalein, quercetin, quercetagetin and naringenin) inhibit various stages of HCMV replication, the most active anti-HCMV compound being baicalein and the less active and less selective being quercetagetin. These drugs could provide potential inhibitors of virus replication alone or in combination, without increased toxicity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25515462	Naringenin chalcon		25515-46-2	Price

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