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Electrochemistry and Analytical Determination of Lysergic Acid Diethylamide (LSD) via Adsorptive Stripping Voltammetry

Daniele Merli, Daniele Zamboni, Stefano Protti, Maria Pesavento, Antonella Profumo

Talanta. 2014 Dec;130:456-61.

PMID: 25159435

Abstract:

Lysergic acid diethylamide (LSD) is hardly detectable and quantifiable in biological samples because of its low active dose. Although several analytical tests are available, routine analysis of this drug is rarely performed. In this article, we report a simple and accurate method for the determination of LSD, based on adsorptive stripping voltammetry in DMF/tetrabutylammonium perchlorate, with a linear range of 1-90 ng L(-1) for deposition times of 50s. LOD of 1.4 ng L(-1) and LOQ of 4.3 ng L(-1) were found. The method can be also applied to biological samples after a simple extraction with 1-chlorobutane.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1923702 Tetrabutylammonium perchlorate Tetrabutylammonium perchlorate 1923-70-2 Price
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