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Electronic Cortisol Detection Using an Antibody-Embedded Polymer Coupled to a Field-Effect Transistor

Electronic Cortisol Detection Using an Antibody-Embedded Polymer Coupled to a Field-Effect Transistor

Hyun-June Jang, Taein Lee, Jian Song, Luisa Russell, Hui Li, Jennifer Dailey, Peter C Searson, Howard E Katz

ACS Appl Mater Interfaces. 2018 May 16;10(19):16233-16237.

PMID: 29701946

Abstract:

A field-effect transistor-based cortisol sensor was demonstrated in physiological conditions. An antibody-embedded polymer on the remote gate was proposed to overcome the Debye length issue (λD). The sensing membrane was made by linking poly(styrene- co-methacrylic acid) (PSMA) with anticortisol before coating the modified polymer on the remote gate. The embedded receptor in the polymer showed sensitivity from 10 fg/mL to 10 ng/mL for cortisol and a limit of detection (LOD) of 1 pg/mL in 1× PBS where λD is 0.2 nm. A LOD of 1 ng/mL was shown in lightly buffered artificial sweat. Finally, a sandwich ELISA confirmed the antibody binding activity of antibody-embedded PSMA.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS73338	Poly(styrene-co-methacrylic acid			Price

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