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Electrospun Poly(l-Lactide-Co-Caprolactone)-Collagen-Chitosan Vascular Graft in a Canine Femoral Artery Model

Electrospun Poly(l-Lactide-Co-Caprolactone)-Collagen-Chitosan Vascular Graft in a Canine Femoral Artery Model

Tong Wu, Bojie Jiang, Yuanfei Wang, Anlin Yin, Chen Huang, Sheng Wang, Xiumei Mo

J Mater Chem B. 2015 Jul 28;3(28):5760-5768.

PMID: 32262572

Abstract:

Poly(l-lactide-co-caprolactone)-collagen-chitosan (P(LLA-CL)-COL-CS) composite grafts were electrospun in this study. Based on the test results for mechanical properties, biodegradability and in vitro cellular compatibility, the optimal weight ratio of P(LLA-CL) to COL/CS was set as 3 : 1. In vivo study was further performed in a canine femoral artery model. The results showed that the 3 : 1 grafts possessed excellent structural integrity, higher patency rate, better endothelial cell (EC) and smooth muscle cells (SMC) growth, as well as higher levels of gene and protein expression of angiogenesis-related cues than those of grafts based on P(LLA-CL). The findings confirmed that the addition of natural materials, such as collagen and chitosan, could effectively improve endothelialization, SMC incursion into the tunica media, and vascular remodeling for tissue engineering.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74356	Poly(L-lactide-co-caprolactone)			Price

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